Smoking, the principal route of cannabis administration in the United States provides a rapid and highly efficient method of drug delivery. Approximately 30% of THC in marijuana or hashish cigarettes is destroyed by pyrolysis during smoking. Drug delivery during cannabis smoking is characterized by rapid absorption of THC. Bioavailablity of smoked THC is reported to be 18-50% partly as a result of the intra- and inter-subject variability in smoking dynamics that contribute to uncertainty in dose delivery. The number, duration and spacing of puffs, hold time, and inhalation volume greatly influence the degree of cannabis exposure.

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Marijuana and the Cannabinoids

Photo shout out to: Kalisha C Everett